In 1742 Pierre Martel (1706–1767), an engineer and geographer living in Geneva, visited the valley of Chamonix in the Alps of Savoy. Two years later he published an account of his journey. He reported that the inhabitants of that valley attributed the dispersal of erratic boulders to the glaciers, saying that they had once extended much farther. Later similar explanations were reported from other regions of the Alps. In 1815 the carpenter and chamois hunter Jean-Pierre Perraudin (1767–1858) explained erratic boulders in the Val de Bagnes in the Swiss canton of Valais as being due to glaciers previously extending further. An unknown woodcutter from Meiringen in the Bernese Oberland advocated a similar idea in a discussion with the Swiss-German geologist Jean de Charpentier (1786–1855) in 1834. Comparable explanations are also known from the Val de Ferret in the Valais and the Seeland in western Switzerland and in Goethe's scientific work. Such explanations could also be found in other parts of the world. When the Bavarian naturalist Ernst von Bibra (1806–1878) visited the Chilean Andes in 1849–1850, the natives attributed fossil moraines to the former action of glaciers.
Meanwhile, European scholars had begun to wonder what had caused the dispersal of erratic material. From the middle of the 18th century, some discussed ice as a means of transport. The Swedish mining expert Daniel Tilas (1712–1772) was, in 1742, the first person to suggest drifting sea ice in order to explain the presence of erratic boulders in the Scandinavian and Baltic regions. In 1795, the Scottish philosopher and gentleman naturalist, James Hutton (1726–1797), explained erratic boulders in the Alps by the action of glaciers. Two decades later, in 1818, the Swedish botanist Göran Wahlenberg (1780–1851) published his theory of a glaciation of the Scandinavian peninsula. He regarded glaciation as a regional phenomenon.
Only a few years later, the Danish-Norwegian geologist Jens Esmark (1762–1839) argued a sequence of worldwide ice ages. In a paper published in 1824, Esmark proposed changes in climate as the cause of those glaciations. He attempted to show that they originated from changes in Earth's orbit. During the following years, Esmark's ideas were discussed and taken over in parts by Swedish, Scottish and German scientists. At the University of Edinburgh Robert Jameson (1774–1854) seemed to be relatively open to Esmark's ideas, as reviewed by Norwegian professor of glaciology Bjørn G. Andersen (1992). Jameson's remarks about ancient glaciers in Scotland were most probably prompted by Esmark. In Germany, Albrecht Reinhard Bernhardi (1797–1849), a geologist and professor of forestry at an academy in Dreissigacker, since incorporated in the southern Thuringian city of Meiningen, adopted Esmark's theory. In a paper published in 1832, Bernhardi speculated about former polar ice caps reaching as far as the temperate zones of the globe.
In 1829, independently of these debates, the Swiss civil engineer Ignaz Venetz (1788–1859) explained the dispersal of erratic boulders in the Alps, the nearby Jura Mountains, and the North German Plain as being due to huge glaciers. When he read his paper before the Schweizerische Naturforschende Gesellschaft, most scientists remained sceptical. Finally, Venetz convinced his friend Jean de Charpentier. De Charpentier transformed Venetz's idea into a theory with a glaciation limited to the Alps. His thoughts resembled Wahlenberg's theory. In fact, both men shared the same volcanistic, or in de Charpentier's case rather plutonistic assumptions, about the Earth's history. In 1834, de Charpentier presented his paper before the Schweizerische Naturforschende Gesellschaft. In the meantime, the German botanist Karl Friedrich Schimper (1803–1867) was studying mosses which were growing on erratic boulders in the alpine upland of Bavaria. He began to wonder where such masses of stone had come from. During the summer of 1835 he made some excursions to the Bavarian Alps. Schimper came to the conclusion that ice must have been the means of transport for the boulders in the alpine upland. In the winter of 1835 to 1836 he held some lectures in Munich. Schimper then assumed that there must have been global times of obliteration ("Verödungszeiten") with a cold climate and frozen water. Schimper spent the summer months of 1836 at Devens, near Bex, in the Swiss Alps with his former university friend Louis Agassiz (1801–1873) and Jean de Charpentier. Schimper, de Charpentier and possibly Venetz convinced Agassiz that there had been a time of glaciation. During the winter of 1836/37, Agassiz and Schimper developed the theory of a sequence of glaciations. They mainly drew upon the preceding works of Venetz, de Charpentier and on their own fieldwork. Agassiz appears to have been already familiar with Bernhardi's paper at that time. At the beginning of 1837, Schimper coined the term "ice age" ("Eiszeit") for the period of the glaciers. In July 1837 Agassiz presented their synthesis before the annual meeting of the Schweizerische Naturforschende Gesellschaft at Neuchâtel. The audience was very critical and some opposed to the new theory because it contradicted the established opinions on climatic history. Most contemporary scientists thought that the Earth had been gradually cooling down since its birth as a molten globe.
In order to overcome this rejection, Agassiz embarked on geological fieldwork. He published his book Study on Glaciers ("Études sur les glaciers") in 1840. De Charpentier was put out by this, as he had also been preparing a book about the glaciation of the Alps. De Charpentier felt that Agassiz should have given him precedence as it was he who had introduced Agassiz to in-depth glacial research. Besides that, Agassiz had, as a result of personal quarrels, omitted any mention of Schimper in his book.