Porphyry reported that Plotinus was 66 years old when he died in 270, the second year of the reign of the emperor Claudius II, thus giving us the year of his teacher's birth as around 205. Eunapius reported that Plotinus was born in the Deltaic Lycopolis in Egypt, which has led to speculations that he may have been a native Egyptian of Roman, Greek, or Hellenized Egyptian descent.
Plotinus had an inherent distrust of materiality (an attitude common to Platonism), holding to the view that phenomena were a poor image or mimicry (mimesis) of something "higher and intelligible" (VI.I) which was the "truer part of genuine Being". This distrust extended to the body, including his own; it is reported by Porphyry that at one point he refused to have his portrait painted, presumably for much the same reasons of dislike. Likewise Plotinus never discussed his ancestry, childhood, or his place or date of birth. From all accounts his personal and social life exhibited the highest moral and spiritual standards.
Plotinus took up the study of philosophy at the age of twenty-seven, around the year 232, and travelled to Alexandria to study. There he was dissatisfied with every teacher he encountered until an acquaintance suggested he listen to the ideas of Ammonius Saccas. Upon hearing Ammonius lecture, he declared to his friend, "this was the man I was looking for," and began to study intently under his new instructor. Besides Ammonius, Plotinus was also influenced by the works of Alexander of Aphrodisias, Numenius, and various Stoics.
After spending the next eleven years in Alexandria, he then decided, at the age of around 38, to investigate the philosophical teachings of the Persian philosophers and the Indian philosophers. In the pursuit of this endeavor he left Alexandria and joined the army of Gordian III as it marched on Persia. However, the campaign was a failure, and on Gordian's eventual death Plotinus found himself abandoned in a hostile land, and only with difficulty found his way back to safety in Antioch.
At the age of forty, during the reign of Philip the Arab, he came to Rome, where he stayed for most of the remainder of his life. There he attracted a number of students. His innermost circle included Porphyry, Amelius Gentilianus of Tuscany, the Senator Castricius Firmus, and Eustochius of Alexandria, a doctor who devoted himself to learning from Plotinus and attending to him until his death. Other students included: Zethos, an Arab by ancestry who died before Plotinus, leaving him a legacy and some land; Zoticus, a critic and poet; Paulinus, a doctor of Scythopolis; and Serapion from Alexandria. He had students amongst the Roman Senate beside Castricius, such as Marcellus Orontius, Sabinillus, and Rogantianus. Women were also numbered amongst his students, including Gemina, in whose house he lived during his residence in Rome, and her daughter, also Gemina; and Amphiclea, the wife of Ariston the son of Iamblichus. Finally, Plotinus was a correspondent of the philosopher Cassius Longinus.