The constituency has always been a safe Labour seat. The current MP is Mike Kane of the Labour Party who was elected at the 2014 by-election in February 2014. He succeeded Labour's Paul Goggins who died in January 2014, and who had held the seat since its inception in 1997.
1997-2010: The City of Manchester wards of Baguley, Benchill, Brooklands, Northenden, Sharston, and Woodhouse Park, and the Metropolitan Borough of Trafford wards of Brooklands, Priory, and Sale Moor.
The constituency of Wythenshawe and Sale East is one of three in the Metropolitan Borough of Trafford and one of five in the City of Manchester, encompassing three of the five electoral wards in Sale and all five wards of Wythenshawe. The constituency was created at the 1997 general election combining most of the former Manchester Wythenshawe constituency with parts of the Altrincham and Sale constituency.